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Results for "

Ligands for E3 Ligase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (4) E3 Ligase Ligand-Linker Conjugates (313) Ligands for E3 Ligase (180) Ligands for Target Protein for PROTAC (11) Target Protein Ligand-Linker Conjugates (10) ADC Cytotoxin (1) ADC Linker (1) Androgen Receptor (1) APC (1) Apoptosis (8) Autophagy (79) Bcl-2 Family (5) BCL6 (1) Bcr-Abl (1) Btk (2) CDK (2) DNA Alkylator/Crosslinker (1) Epigenetic Reader Domain (3) Estrogen Receptor/ERR (2) FAK (1) FKBP (2) GLP Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (4) Isotope-Labeled Compounds (1) MDM-2/p53 (4) MEK (1) Molecular Glues (6) PERK (1) PROTAC Linkers (10) PROTACs (28) Ras (1) SHP2 (1) Sirtuin (1) SNIPERs (1) STAT (1) α-synuclein (1)
By Research Areas:	Cancer (533) Inflammation/Immunology (14) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	PROTAC Synthesis (2) Azide (31) Alkynes (4)

556

Inhibitors & Agonists

Screening Libraries

Isotope-Labeled Compounds

Click Chemistry

BWA-522 intermediate-1	Ligands for E3 Ligase	Cancer
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7 .

*E3 ligase* Ligand 18**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

DCAF1 binder 2	Others	Others
DCAF1 binder 2, a **ligands for E3 Ligase**, involves in BRD9, kinase and selective BTK degration.

Pomalidomide-5-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates PROTACs	Cancer
Pomalidomide-5-C2-NH2 (hydrochloride) is used to synthesize E3 ligase ligand and linker conjugates for PROTACs .

*E3 ligase* Ligand 10**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 ligase* Ligand 14**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 ligase* Ligand 8** 3 Publications Verification	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 ligase* Ligand 13**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

E3 ubiquitin ligase binder-1	Ligands for E3 Ligase	Cancer
E3 ubiquitin ligase binder-1 (compound 11) is a potent E3 ubiquitin ligase binder. E3 ubiquitin ligase binder-1 is a ligand for E3 Ligase .

*E3 ligase* Ligand 9**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 Ligase* Ligand-Linker Conjugate Kit**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-Linker Conjugate Kit is a series of synthesized compounds that incorporate an E3 ligase ligand and a linker used in PROTAC technology.

*E3 ligase* Ligand-Linker Conjugate 29**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 29 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 29 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

(S)-Thalidomide-Piperazine-CH2-Pyrrolidine-C2-OH	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 30 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 30 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 37**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 37 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 37 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 38**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 38 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 38 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 65**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 65 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 65 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 66**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 66 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 66 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 92**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 92 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 92 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 93**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 93 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 93 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 94**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 94 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 94 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 99**	Ligands for E3 Ligase Autophagy E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 99 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 100**	Ligands for E3 Ligase Autophagy E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 100 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 100 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 104**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 104 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 104 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 105**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 105 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 105 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 106**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 106 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 106 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 2**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 2 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 5**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 5 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 5 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 7**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 7 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 7 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 9**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 9 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 9 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 11**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 11 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 11 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 12**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 12 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 12 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 13**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 13 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 13 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 14**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 14 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 14 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 16**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 16 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 16 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 17**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 17 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 17 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 18**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 18 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 18 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 20**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 20 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 20 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 28**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 28 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 28 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 34**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 34 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 34 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 39**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 39 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 39 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 41**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 41 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 41 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 43**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 43 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 43 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 45**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 45 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 45 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 47**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 47 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 47 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 51**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 51 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 51 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 54**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 54 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 54 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

Cat. No.	Product Name

HY-L128

E3 Ligase Ligand Library

88 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 88 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L129

Target Protein Ligand Library

39 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 39 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

Cat. No.	Product Name		Classification

HY-126458

Thalidomide-O-PEG2-propargyl E3 Ligase Ligand-Linker Conjugates 32		Alkynes
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized *E3 ligase* ligand-linker conjugate** (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-163167

VH 032 amide-alkylC5-azide		Azide
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-160077

Pomalidomide-CO-C5-azide		Azide
Pomalidomide-CO-C5-azide (Compound PA) is a **ligand for E3 ligase bearing a bioorthogonal group azide. Pomalidomide-CO-C5-azide can be used to synthesize PROTACs** with anticancer activity .

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the *E3 ligase* ligand-linker conjugate** used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-128767

VH032-PEG3-acetylene		Alkynes
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology . VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-69220

7-Octynoic acid		PROTAC Synthesis Alkynes
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-137537

Pomalidomide-PEG2-azide		Azide
Pomalidomide-PEG2-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon Ligand-Linker Conjugates 4; E3 Ligase Ligand-Linker Conjugates 18		Azide
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 Ligase Ligand-Linker Conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103599

(S,R,S)-AHPC-PEG2-N3 VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 Ligase Ligand-Linker Conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; E3 Ligase Ligand-Linker Conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103601

(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 Ligase Ligand-Linker Conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-139999

LCL-PEG3-N3		Azide
LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-139999A

LCL-PEG3-N3 hydrochloride		Azide
LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-108374

4-Azidobutylamine		PROTAC Synthesis Azide
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		Azide
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a *crosslinker-E3 ligase* ligand conjugate**, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader .

HY-161131

Lenalidomide 4'-alkyl-C3-azide		Azide
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 48		Azide
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-133138

Pomalidomide-PEG1-azide		Azide
Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131) . Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-133139

Lenalidomide-PEG1-azide		Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130652

Pomalidomide 4'-PEG3-azide		Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-Linker Conjugates 13; E3 Ligase Ligand-Linker Conjugates 50		Azide
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM . (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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